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As a result of the current anthrax scare, another fluorinated medication called Cipro has received extensive media coverage and the name has become familiar to millions almost in an instant. As soon as the first cases of anthrax resulted from suspicious mail became known, there were wide reports of a hectic run on this medication.
Mass hysteria seems to happen as governments, pharmacies and individuals everywhere are stockpiling Cipro. People now days are thinking that because of flu liked symptoms they are taking in Cipro that includes giving it to their children.
Cipro is ciprofloxacin, a fluorinated quinolone, that belongs to a class of fluorinated antibiotics which also include temafloxacin, enoxacin, fleroxacin, grepafloxacin, norfloxacin, sparfloxacin, tosufloxacin, lomefloxacin and ofloxacin.
Ciprofloxacin has been in the market since 1987 for a variety of other indications and is the most widely used fluoroquinolone in humans and animals worldwide.
In 2000, the FDA licensed its use as a treatment for inhalational anthrax under its accelerated approval regulations. The FDA had actually taken the unusual step of urging Bayer-- the only manufacturer for all countries except India to file for such approval, supposedly in order to protect everyone from future terrorist attacks. The US Department of Defense had already ordered bulk of Cipro during the 1991 Gulf War.
Grepafloxacin and Temafloxacin are two other fluoroquinolones now withdrawn from the market because they had caused extreme liver and renal damage and even deaths, just like fluorinated drugs from other, different classifications, such as Baycol. Fatal liver failure connected with ciprofloxacin was reported in the Lancet in 1994.
Ciprofloxacin has been linked in several cases of acute renal failure and is the fluoroquinolone most established to cause such renal dysfunction.
The most common side-effects due to Cipro, reported in 2-16 percent of cases, are gastrointestinal in nature and equal those reported when pediatric patients accidentally ingest too much fluoride from their toothpaste. These symptoms include diarrhea,nausea, vomiting and abdominal pain.
Ciprofloxacin administration always results in increase serum fluoride levels. In a series of tests evaluating the safety of ciprofloxacin in the use of children, serum fluoride levels increased after 12 hours in 79 percent of the children; on day 7 the 24-hour urinary fluoride excretion was higher in 88.9 percent of children observed.